解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We aimed to create transgenic (Tg) mice engineered for magnetic resonance imaging (MRI). To ascertain if MagA expression contributes to oxidative stress and iron metabolism, we report the generation of Tg mice in which ubiquitous expression of MagA can be detected by MRI in vivo. Expression of MagA in diverse tissues ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1090029
更新日期:2016-01-01 00:00:00
abstract::Nano-titanium dioxide (nano-TiO2) is one of the most universal engineered nano-materials while perfluorooctanesulfonate (PFOS) is a typical new persistent organic pollutant. They are widely used and present in aquatic environment. In this study, a novel semi-static multilayer microcosm was setup to investigate the imp...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1084058
更新日期:2016-01-01 00:00:00
abstract::Here, we evaluate the extent of sorption of silver nanoparticles (AgNPs) with different primary sizes (30 and 70 nm) and surface properties (branched polyethylene imine, "bPEI" and citrate coating) to laboratory plastic during (eco)toxicological testing. Under conditions of algal growth inhibition assay, up to 97% of ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1084059
更新日期:2016-01-01 00:00:00
abstract::Our group already demonstrated that europium hydroxide nanorods (EHNs) show none or mild toxicity in C57BL/6 mice even at high dose and exhibited excellent pro-angiogenic activity towards in vitro and in vivo models. In the present study, we evaluated the in vivo cytogenetic toxicity of intraperitoneally administered ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1073398
更新日期:2016-01-01 00:00:00
abstract::Growing experimental evidences suggest the existence of direct relationships between the surface chemistry of nanomaterials and their biological effects. Herein, we have employed computational approaches to design a set of biologically active carbon nanotubes (CNTs) with controlled protein binding and cytotoxicity. Qu...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1073397
更新日期:2016-01-01 00:00:00
abstract::Despite the rapid ongoing expansion in the use of nanomaterials, we still know little about their biological interaction and biodistribution within the human body. If medically relevant nanoparticles can cross specific cell barriers they may disseminate through the body beyond the original target and may reach particu...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.833317
更新日期:2015-05-01 00:00:00
abstract::Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics and targeted drug delivery. We investigated the potential cytotoxicity and genotoxicity of uncoated iron oxide (U-Fe3O4) NPs in comp...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.847505
更新日期:2015-05-01 00:00:00
abstract::Dendrimers are nanosized hyperbranched polymers synthesized through an iterative step-by-step process; their size and structure are perfectly controlled, and they are widely used for biomedical purposes. Previously, we showed that a phosphorous-based dendrimer capped with anionic AzaBisPhosphonate groups (so-called AB...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.940406
更新日期:2015-05-01 00:00:00
abstract::The effect of non-functionalized and amino-functionalized multiwall carbon nanotube (CNT) exposure, as well as the impact of CNT presence on coexistent pesticide accumulation, was investigated in lettuce (Lactuca sativa L.). Lettuce seeds were sown directly into CNT-amended vermiculite (1000 mg L(-1)) to monitor phyto...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.907456
更新日期:2015-03-01 00:00:00
abstract::Inhalation of zinc oxide nanoparticles (ZnONP) has potential health impact. Because zinc ion may involve in the toxicity of ZnONP, we compared adverse effects of inhaled aerosolized ZnONP and zinc nitrate in mice. Aerosolized ZnONP and zinc nitrate were well-dispersed in the inhalation chamber. Inhalation of 0.86 mg/m...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.886740
更新日期:2015-02-01 00:00:00
abstract::The lung provides the main route for nanomaterial exposure. Surfactant protein A (SP-A) is an important respiratory innate immune molecule with the ability to bind or opsonise pathogens to enhance phagocytic removal from the airways. We hypothesised that SP-A, like surfactant protein D, may interact with inhaled nanop...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.992487
更新日期:2015-01-01 00:00:00
abstract::We evaluated and compared the pulmonary clearance kinetics and extrapulmonary translocations of seven titanium dioxide (TiO2) nano- and submicron particles with different characteristics, including size, shape and surface coating. Varying doses of TiO2 nano- and submicron particles dispersed in 0.2% disodium phosphate...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1015644
更新日期:2015-01-01 00:00:00
abstract::Certain types of carbon nanotubes (CNT) can evoke inflammation, fibrosis and mesothelioma in vivo, raising concerns about their potential health effects. It has been recently postulated that NLRP3 inflammasome activation is important in the CNT-induced toxicity. However, more comprehensive studies of the protein secre...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.969346
更新日期:2015-01-01 00:00:00
abstract::Despite the increasing commercial use of nanoparticles, little is known about their effects on placental inflammation and pregnancy complications. In this study, nanosilica (NS) particles upregulated the inflammasome component nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.956156
更新日期:2015-01-01 00:00:00
abstract::Silver nanoparticles (Ag-NPs) are used in a wide variety of products, prompting concerns regarding their potential environmental impacts. To accurately determine the toxicity of Ag-NPs it is necessary to differentiate between the toxicity of the nanoparticles themselves and the toxicity of ionic silver (Ag) released f...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.994570
更新日期:2015-01-01 00:00:00
abstract::In our previous studies of nanocalcium carbonate, in which we performed physicochemical analysis, genotoxicity, acute single-dose and repeated-dose 14-day oral toxicity testings in Sprague-Dawley (SD) rats, nanocalcium carbonate did not show a difference in toxicity compared to vehicle control. Here, we provide the fi...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.958587
更新日期:2015-01-01 00:00:00
abstract::Administration of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs, 10 µg intravenously on alternate days) induced a sustained anemia in mice. Using a modified double in vivo biotinylation (DIB) technique, blood counts of reticulocytes and erythrocytes of different age groups were simultane...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.998307
更新日期:2015-01-01 00:00:00
abstract::The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.976603
更新日期:2015-01-01 00:00:00
abstract::Raphidocelis subcapitata is a freshwater algae species that constitutes the basis of many aquatic trophic chains. In this study, R. subcapitata was used as a model species to investigate the kinetics of uptake and elimination of silver nanoparticles (AgNP) in comparison to silver nitrate (AgNO3) with particular focus ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.963724
更新日期:2015-01-01 00:00:00
abstract::Due to the increasing use of nanometric cerium oxide in applications, concerns about the toxicity of these particles have been raised and have resulted in a large number of studies. We report here on the interactions between 7 nm anionically charged cerium oxide particles and living mammalian cells. By a modification ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.831501
更新日期:2014-11-01 00:00:00
abstract::To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.822116
更新日期:2014-09-01 00:00:00
abstract::Engineered nanoparticles are increasingly used in medical applications and day-to-day consumer products, leading to concerns about the potential environmental and human health impacts. Silver nanoparticles are particularly prevalent because of their use as anti-bacterial agents in many commonly available products. Nan...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.866284
更新日期:2014-08-01 00:00:00
abstract::Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known abou...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.801089
更新日期:2014-08-01 00:00:00
abstract::Abstract To examine gold nanoparticle reprotoxicity, bovine spermatozoa were challenged with ligand-free or oligonucleotide-conjugated gold nanoparticles synthesized purely without any surfactants by laser ablation. Sperm motility declined at nanoparticle mass dose of 10 µg/ml (corresponding to ∼14 000 nanoparticles p...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.859321
更新日期:2014-08-01 00:00:00
abstract::The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.779757
更新日期:2014-05-01 00:00:00
abstract::Little information exists on the toxicological hazards associated to organo-modified clays. We evaluated the cytotoxicity of a series of pristine and organo-modified nanoclays in different cell lines. The calculated IC50 values for cell viability ranged from 1.4 to 47 µg/mL for the six organoclays used and were above ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.776123
更新日期:2014-05-01 00:00:00
abstract::Enhanced in vitro human and ex vivo rat platelet aggregation from direct exposure to silver nanoparticles is previously reported. Given the increasing human use of engineered silver nanoscale products, platelet aggregation prompted by silver nanoparticles may contribute to human cardiovascular events. To understand ho...
journal_title:Nanotoxicology
pub_type: 临床试验,杂志文章
doi:10.3109/17435390.2013.788749
更新日期:2014-05-01 00:00:00
abstract::In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, and their toxicity as well as biodistribution were evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrat...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.760014
更新日期:2014-02-01 00:00:00
abstract::Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.735268
更新日期:2013-12-01 00:00:00
abstract::This study aims to assess the effects of Ag particles synthesised by a chemical (Ag 20, 200 nm) and biological method (Ag 23, 27 nm) in aquatic organisms: the bacterium Vibrio fischeri, the alga Desmodesmus subspicatus and the crustacean Daphnia magna. Ag particles exerted toxic effects in all organisms studied with A...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.715312
更新日期:2013-11-01 00:00:00
abstract::Since nanomaterials are a heterogeneous group of substances used in various applications, risk assessment needs to be done on a case-by-case basis. Here the authors assess the risk (hazard and exposure) of a glass cleaner with synthetic amorphous silicon dioxide (SAS) nanoparticles during production and consumer use (...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.689881
更新日期:2013-08-01 00:00:00
abstract::The increasing presence of ZnO nanoparticles (NPs) in consumer products may be having a dramatic impact in aquatic environments. The evaluation of ZnO NP toxicity represents a great challenge. This study aimed at evaluating the cytotoxic effect of micro- and nanosized ZnO in a fish and a mammalian hepatoma cell line. ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.676098
更新日期:2013-08-01 00:00:00
abstract::ZnO nanoparticles (NPs) elicit significant adverse effects in various cell types, organisms and in the environment. The toxicity of nanoscale ZnO has often been ascribed to the release of zinc ions from the NPs but it is not yet understood to which extent these ions contribute to ZnO NP toxicity and what are the under...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.666575
更新日期:2013-06-01 00:00:00
abstract::The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 μg Ag/mouse. Mice were eut...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.626539
更新日期:2012-12-01 00:00:00
abstract::The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.604442
更新日期:2012-11-01 00:00:00
abstract::The widespread increase in the production and use of nanomaterials has increased the potential for nanoparticle exposure; however, the biological effects of nanoparticle inhalation are poorly understood. Rats were exposed to nanosized titanium dioxide aerosols (10 μg lung burden); at 24 h post-exposure, the spinotrape...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.606926
更新日期:2012-11-01 00:00:00
abstract::The levels of exposure and internal doses of nanomaterials are becoming more and more important for estimating the health effects resulting from exposure to nanomaterials. Health surveillance can be used as an indicator of whether exposure is occurring, rather than in determining if levels of exposure are safe. We hav...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.600840
更新日期:2012-09-01 00:00:00
abstract::Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m(3) Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, wit...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.587902
更新日期:2012-08-01 00:00:00
abstract::Nanosized zeolite particles are important materials for many applications in the field of nanotechnology. The possible adverse effects of these nanomaterials on human health have been scarcely investigated and remain largely unknown. This study reports the synthesis of nanozeolites Y and A with particle sizes of 25-10...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.587901
更新日期:2012-08-01 00:00:00
abstract::Cellular adaptation is the dynamic response of a cell to adverse changes in its intra/extra cellular environment. The aims of this study were to investigate the role of: (i) the glutathione antioxidant system, and (ii) the transcription factor EB (TFEB), a newly revealed master regulator of lysosome biogenesis, in cel...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.572195
更新日期:2012-05-01 00:00:00